Many women with PCOS are resistant to insulin, and this is especially true in cases of women who are overweight or obese, have unhealthy eating habits, live sedentary lifestyles, or have a family history of diabetes. Insulin resistance describes a hormonal state in which your body is less able to send the proper amount of glucose to the cells. In turn, the pancreas produces more insulin to stabilize glucose levels. The extra insulin in your body causes several negative effects on the body, including the ovaries, leading to higher levels of male hormones.