Menopause is another stage of life and marks the end a woman’s reproductive lifespan. Menopause happens when the ovaries stop making estrogen. Most commonly, this occurs naturally in women > 40 years of age who have no period (spontaneous amenorrhea) for ≥12 consecutive months.
Some women are diagnosed with menopause if they have:
- no period ≥6 months with biochemical criteria of menopause (FSH >40 IU/L) OR
- Spontaneous amenorrhea for ≥3 months with FSH >40 IU/L and estradiol (E2) <0.21 nmol/L OR
- Removal of both ovaries (bilateral oophorectomy) ≥6 weeks prior to screening