Most prescription medications contain estrogen and are used directly in the vagina. These include:
- Creams - Estrace cream; Premarin cream
- Rings - Estring; Femring
- Vaginal tablets - Estrace vaginal tablets; Vagifem
The only vaginal non-estrogen treatment for moderate to severe painful sex due to menopause is the vaginal insert, prasterone, also know as dehydroepiandrosterone (DHEA) (Brand: INTRAROSA).
Ospemifene (Osphena) oral tablets are the first and only once-daily, oral, non-hormonal treatment for vaginal dryness and painful intercourse.