People with SS will likely stay in the hospital for at least 24 hours for close observation.
Treatment may include:
- Benzodiazepine medicines, such as diazepam (Valium) or lorazepam (Ativan) to decrease agitation, seizure-like movements, and muscle stiffness
- Cyproheptadine (Periactin), a drug that blocks serotonin production
- Intravenous (through the vein) fluids
- Withdrawal of medicines that caused the syndrome
In life-threatening cases, medicines that keep the muscles still (paralyze them), and a temporary breathing tube and breathing machine will be needed to prevent further muscle damage.