How long will it take me to lose weight on weight loss medication? April 27, 2021 20:13 Updated Most weight loss occurs within the first 6 months of starting the weight-loss medication. Related articles What kind of health benefits can I expect from taking weight-loss medication? What are tips for taking weight-loss medication? Will I regain some weight after I stop taking weight-loss medication? How do weight-loss medications work? How might weight-loss medications help me?